Mitonuclear epistasis and mitochondrial disease
نویسندگان
چکیده
منابع مشابه
Fishing for adaptive epistasis using mitonuclear interactions
Mitochondria provide us with the energy to get up and do what needs to be done. They do this with 37 genes encoded in their own genome and more than 1,200 genes from the nuclear genome, whose gene products are targeted to mitochondria after being translated on cytosolic ribosomes. This complex intergenomic communication is a hallmark of eukaryotic life and has been under continuous refinement f...
متن کاملMitonuclear Epistasis for Development Time and Its Modification by Diet in Drosophila.
Mitochondrial (mtDNA) and nuclear genes have to operate in a coordinated manner to maintain organismal function, and the regulation of this homeostasis presents a substantial source of potential epistatic (G × G) interactions. How these interactions shape the fitness landscape is poorly understood. Here we developed a novel mitonuclear epistasis model, using selected strains of the Drosophila G...
متن کاملEvolution Meets Disease: Penetrance and Functional Epistasis of Mitochondrial tRNA Mutations
About half of the mitochondrial DNA (mtDNA) mutations causing diseases in humans occur in tRNA genes. Particularly intriguing are those pathogenic tRNA mutations than can reach homoplasmy and yet show very different penetrance among patients. These mutations are scarce and, in addition to their obvious interest for understanding human pathology, they can be excellent experimental examples to mo...
متن کاملAging: Seeking Mitonuclear Balance
Metabolic imbalances accompany the aging process in many organisms, and signaling mechanisms that allay or prevent these imbalances can extend lifespan. Two recent studies by Auwerx and colleagues, including one in this issue, identify a conserved signaling network centered on mitochondrial stress responses that promotes longevity in response to changes in mitochondrial translation and NAD(+) m...
متن کاملMitonuclear coevolution as the genesis of speciation and the mitochondrial DNA barcode gap
Mitochondrial genes are widely used in taxonomy and systematics because high mutation rates lead to rapid sequence divergence and because such changes have long been assumed to be neutral with respect to function. In particular, the nucleotide sequence of the mitochondrial gene cytochrome c oxidase subunit 1 has been established as a highly effective DNA barcode for diagnosing the species bound...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Mitochondrion
سال: 2017
ISSN: 1567-7249
DOI: 10.1016/j.mito.2017.06.001